Our phase IV clinical studies alone cannot establish cause-effect relationship. Learn which foods you should avoid if you have thyroid disease of any type. If your current doctor is unwilling to order these tests then you may need to seek out a second opinion and look for someone who specializes in thyroid care. The half-life of Cytomel is about 2.5 days and experts agree that it takes up to 5 half-lives for a drug . See our full disclaimer in "Terms of use.". The normal subjects were placed on T3 doses of 50 mcg daily the 1st wk, 75 mcg daily the 2nd wk; and 100 mcg daily for the last 10 d., The athyreotic patients were switched from oral thyroxine replacement to oral T3 (Cytomel), 75 mcg daily., There was only one dose per day. This may include weight loss, fever, headache, anxiety, trouble sleeping, arrythmias, and heart failure. 2023 eHealthMe.com. The withdrawal process affects everyone differently in terms of symptoms and severity. Ordering and obtaining all of the thyroid lab tests will help give you information about how well you are absorbing thyroid medication, how well you are utilizing it in your body, how your body is metabolizing/converting it, and so on. Peripheral Tissue Mechanism for Maintenance of Serum Triiodothyronine Values in a Thyroxine-Deficient State in Man. Journal of Clinical Investigation 73 (2): 57075. How did clinical experience suggest this? Its possible, that through incorrect testing of an isolated TSH test, patients can be placed on thyroid medication inappropriately. Breastfeeding women should discuss the benefits and risks of Thyrogen with their physician. Side Effects. Thyroid patient since 2003. Some symptoms are more predictably responsive than others. The benefit of LT3 withdrawal in comparison to LT4 was that LT3 cut the post-withdrawal suffering time in half (2 weeks) by speeding up the rise of TSH. It is most commonly used to treat hypothyroidism and myxedema coma. Learn more. 3. headaches and muscle aches. The next step, which hopefully follows #1, is to take a hard look at which medication you are currently using. Drug cravings. In the treatment and follow up of thyroid cancer, for certain procedures, you need a high level of thyroid stimulating hormone (TSH). Because when the thyroid hormone levels are high, this gives the signal to your body to run at a very high speed. The list includes optimal ranges, normal ranges, and the complete list of tests you need to diagnose and manage thyroid disease correctly! Simultaneous Measurement of Thyroxine and Triiodothyronine Peripheral Turnover Kinetics in Man. The Journal of Clinical Investigation 51 (3): 47383. Children:Safety and effectiveness in young patients (under the age of 18) have not been established. Dosing T3 in light of circadian rhythm Thyroid Patients Canada, Ingbar and Bravermans historic study of LT4 monotherapy Thyroid Patients Canada, Free T3 peaks and valleys in T3 and NDT therapy Thyroid Patients Canada, Focusing on T3: The T3 hormone or the LT3 pharmaceutical? CYTOMEL: Side Effects, Reviews by Patients - AskaPatient.com This lab panel includes the following tests: TSH, free t3, free t4, reverse T3, thyroid antibodies, and sex hormone-binding globulin. https://doi.org/10.1089/thy.2009.0187. Lastly, some people make the assumption that taking thyroid supplements (such as those available over the counter) may allow them to stop taking their thyroid medication. All information is observation-only. This normal axis is disrupted when you take any sort of thyroid medication (T4 or T3 or otherwise). TSH stands for thyroid stimulating hormone because it stimulates the production and release of thyroid hormone from your thyroid gland. I go to great lengths to help my users better understand their health; however, the content you see here is not a substitute for medical advice. Stages of Thyroid Cancer . The survey minimized several debilitating symptoms such as fatigue, insomnia, cold intolerance, and weight gain. Effects of the drug can wear off fairly quickly. Ive discussed various options for patients post-thyroidectomy in this post here. Problems sleeping, including insomnia and/or fatigue. This should happen eventually, but you also have to consider the fact that your body may not be able to even produce a normal amount by itself (thus the requirement for additional thyroid hormone through medication). Loss of ability to experience pleasure. How buy steroids online Made Me A Better Salesperson (The study did not mention any adverse side effects experienced by the euthyroid people who ended up dosing 100 mcg/day under supervision. June 12, 2022 June 12, 2022 0 Comments June 12, 2022 0 Comments Twenty-Four Hour Variations of Triiodothyronine (T3) Levels in Patients Who Had Thyroid Ablation for Thyroid Cancer, Receiving T3 as Suppressive Treatment. Journal of Endocrinological Investigation 3 (4): 35356. (HAM-A) = Hamilton Anxiety Scale At peak levels, a properly dosed LT3 patient with healthy adrenals will not experience any thyrotoxic symptoms. Have you thought about discontinuing your medication? He recently came off the Cytomel and is feeling pretty bad. Erlotinib Hydrochloride and Fungal Sepsis, Amlodipine Besylate and Vitamins drug interaction, Headache (pain in head): 8 people, 25.81%, Drug Administration Error: 5 people, 16.13%, Mobility Decreased (ability to move is reduced): 5 people, 16.13%, Drug Exposure During Pregnancy: 4 people, 12.90%, Malaise (a feeling of general discomfort or uneasiness): 4 people, 12.90%, Headache (pain in head): 5 people, 16.13%, Arthritis (form of joint disorder that involves inflammation of one or more joints): 5 people, 16.13%, Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 16.13%, Neuropathy Peripheral (surface nerve damage): 5 people, 16.13%. Check whether Withdrawal syndrome is associated with a drug or a condition, Withdrawal syndrome and drugs with ingredients of liothyronine sodium, Withdrawal syndrome in Moderna COVID Vaccine, Withdrawal syndrome in Pfizer BioNTech Covid Vaccine, Withdrawal syndrome in Johnson and Johnson Covid Vaccine, Desvenlafaxine Succinate and Fluticasone Propionate drug interaction. I am a former Doctor of Osteopathic Medicine (no longer practicing) that now focuses on producing the information you see here while also formulating some of the best supplements on the market (in my HUMBLE opinion) :). The body tries to compensate by neurovascular adaptations including chronic peripheral vasoconstriction, mild diastolic hypertension, and diminished blood volume. (Mathew et al, 2011). You can take part in a withdrawal program in: a residential detox unit or in a hospital. Cytomel (Liothyronine) - Side Effects, Interactions, Uses, Dosage The lower your TSH goes the more your body is reliant upon thyroid medication for thyroid hormone. In clinical studies, the most common side effects reported were nausea and headache. 6,191 people reported to have side effects when taking Cytomel. diarrhoea. Mood swings. They are most likely (more than probable) from coming off the Zoloft. Liothyronine Sodium - an overview | ScienceDirect Topics https://doi.org/10.1111/j.1365-2265.2009.03700.x. However, the basis of the working mechanism of each steroid is testosterone. Even some supplements, such as iodine, can alter this axis. It is used to treat conditions such as arthritis, blood / hormone / immune system disorders . This process is called thyroid hormone withdrawal (THW). Also, when our thyroid functions normally, it produces T4 to T3 in a ratio of about 20 to 1. 1983. Just realize that some people may feel better when they stop the medication, but the exact reason should be evaluated on the individual level. T3 (Cytomel) Overview - What To Expect - More Plates More Dates To put that in context, thereference rangeof total triiodothyronine (T3) is approximately 80-220 ng/dL in adults. This is an important question for many people who dose LT3. Get medical help right away, if you have any of the symptoms listed above. Stage 2 (24-72 hours after the last drink): The common symptoms during this stage are high blood pressure . rapidly changing moods. Diet and exercise by themselves are probably not enough to cure your condition (though they may for some) but they will allow you to feel better, help maintains your weight, and improves thyroid function. The pathological state of Myxedema Coma, in which 50% of patients die (Dutta et al, 2008), is defined as decompensated hypothyroidism because the compensatory mechanisms have failed and thyroid hormone supplementation arrives too late. When Thyrogen is used to help detect thyroid cancer, there is still a chance all or parts of the cancer could be missed. I then conclude with data from a survey showing the harm to quality of life of even a short-term LT3 withdrawal, and a discussion of the serious health risks of withdrawal. When you take thyroid hormone it causes a feedback loop that inhibits the natural production of TSH from your pituitary gland. Weakness, lethargy, cold intolerance, paleness, dry skin, coarse hair, and constipation can occur with acute hypothyroidism. If you take Cytomel once daily and notice symptoms of hypothyroidism getting worse as the day progresses, speak to your doctor about the possibility of . cytomel withdrawal symptoms - Bridgesofkentucky.com If you spend any time researching on the internet you will always find someone who has a positive experience when they stop taking their medication. The score of 3 was reserved for always, which would not be likely for the LT4 patients on 4 weeks of withdrawal given the slow clearance rate of LT4. The answer to people in this category may be as easy as increasing your medication. Get my free thyroid downloads, resources, and PDFs here. The initial dose of CYTOMEL varies with age and body weight. The most severe and deadly cases, according to Dutta et al, are not among those who were previously undiagnosed, but rather among the people who stopped their thyroid therapy. Cerebral Blood Flow and Glucose Metabolism in Hypothyroidism: A Positron Emission Tomography; The Journal of Clinical Endocrinology & Metabolism, Volume 86, Issue 8, 1 August 2001, Pages 38643870,https://doi.org/10.1210/jcem.86.8.7749. In all but one patient who had a functional thyroid remnant, Total T3 levels fell below the assays limit of detection [LOD]. This group of people should never make changes to their thyroid medication without physician supervision as it can be very dangerous. For obvious reasons, no one does studies testing the limits of human hypothyroidism beyond rare case studies and retrospective observational studies. Resources, a Lee et als patients given LT3 had been treated with LT4 prior to only 2 weeks of LT3 monotherapy, so they still likely had LT4 in bloodstream 2 weeks post-withdrawal. It does not take long for T3 to fall to harmful and then to dangerous levels in persons who do not have concurrent T4 supply. nausea. This content is strictly the opinion of Dr. Westin Childs and is for educational and information purposes only. It is based on liothyronine sodium (the active ingredients of Cytomel) and Cytomel (the brand name). Thyrogen should be given to a pregnant woman only if the doctor thinks there is a clear need for it. Cytomel Side Effects: Complete List + Dosing Guide for Patients At 22 hours, most of the transient peak was long gone. Common side effects of Cytomel include: nausea. Patients should remain hydrated prior to treatment with Thyrogen. Withdrawal of exogenous l-thyroxine for 6 weeks before the scan allows the protein-bound fraction of the hormone to be exhausted. Cytomel is an FDA-approved tablet medication used to replace the T3 thyroid hormone. Unsurprisingly, patients quality of life (QoL) suffered. TSH is part of an important axis known as the hypothalamic-pituitary-thyroid axis (5). Anxiety. So if you start it again having waited five days the experience is very likely not to be nearly as hyper if at all. Posted on 1 second ago; June 24, 2022 . Call1-88-THYROGENto speak with a Case Manager. LT3 monotherapy is often taken in several divided doses per day.). This prevented their TSH from rising higher and their T3 from falling lower by the end of 2 weeks withdrawal. Nicoloff et als 1972 report showed the following graph for clearance rates of an injection of T3 that was tagged by radioactive iodine. Jun 2022 24. spezzatino al sugo con patate in pentola a pressione Facebook; unexpected wedding readings Twitter; mon voisin fume de l'herbe et ca sent chez moi Google+; thomas wright obituary 2021 . Thyroid medication is always more potent and more powerful than any supplement (available over the counter). (former Osteopathic Physician). Symptoms that impair complex and demanding tasks may appear long before the half life of the dose if one starts from a position of LT3-dependent euthyroidism (Busnardo et al, 1983) and then progresses all the way to depletion of T3 without any T4 support. Does that mean that you need to suffer from any existing symptoms? Cytomel (Liothyronine) received an overall rating of 7 out of 10 stars from 40 reviews. The worst symptom seems to be the head fog - he can't focus or get anything done - so he says. But its not safe to assume that supplements have the ability to replace thyroid medication. Learn More Integer gravida Check with your doctor immediately if any of the following side effects occur: Incidence not known. Its far better, instead, to try other therapies (which are proven to be effective) with a knowledgeable physician. 7 Common Withdrawal Symptoms | Quit Smoking - CDC decreased bone mineral density. Among them, 31 people (0.5%) have Withdrawal syndrome. What Happens When You Don't Take Your Thyroid Medication - Verywell Health Douglas Van Nostrand, M.D., Gary Bloom, and Leonard . It is believed that the health emergency of myxedema crisis is found in long term untreated hypothyroidism, and that only the chronic phase of Low T3 syndrome is pathological (Fliers et al, 2015). Is your current physician unwilling to work with you to try something new? I have no other symptoms such as headache, sore throat, nausea. . The peak T3 levels shown in the graph were the transient maximum. In many cases, adding some T3 to your current medication regimen is enough to improve your symptoms dramatically. P.S. Studies of T3 half life are often performed in thyroid-healthy subjects on a short-term basis after taking a single large dose. cytomel withdrawal symptoms - MedHelp Synthroid 20mg/50mg Buy Levothyroxine After withdrawal, some symptoms do not appear until after the medication has disappeared from circulation, due to the long-term and cumulative nature of thyroid hormone signalling. LT3 monotherapy is often taken in several divided doses per day.) Dosage of drugs is not considered in the study. Stress may not always be within your control, but what you can control is how well you cope with it by adding certain techniques. Liothyronine: answering patients' questions. Excerpted, with permission, from pages 92-93 of "Withdrawal of Thyroid Hormones," Chapter 915of the reference book "Thyroid Cancer: A Guide for Patients", Keystone Press, 2010. The first half of the half life describes a steep crash; the decline past the half-life takes a much longer time. (This is not common. In pediatric patients in whom a diagnosis of permanent hypothyroidism has not been established, discontinue . These supplements can be used in conjunction with your existing thyroid medication and with other therapies, which makes them great for layering therapies on top of each other. What happens if you stop the T3 therapy abruptly? Dehydration is common during withdrawal. The answer is, not without some extreme suffering. cytomel withdrawal symptoms; joaquin niemann sponsors. Their goal is not clearance of T3, but a target TSH that will strongly stimulate the thyroid remnant to take up the radioactive iodine. Im not depressed and my daughter is 11 years old. The exception would be if you are starting a new medication, altering your dose or if you are doing it with physician supervision. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. This means that there are some people (up to 15% of the population based on genetic studies) who simply dont do well on T4-only thyroid medication. The thyroid is like the engine of your body. The T3 remaining by day 8 was buoyed up by T4-T3 conversion: The mean serum T4 values in the athyreotic group were 0.40.1 mcg/dl, indicating that residual T4 was present from previous T4 therapy. Never make any assumptions about your body or your thyroid function based on someone elses experience. The reason that this is so important is that, without it, you are really flying blind. This medication comes in tablet form to be taken once daily. It is not known whether Thyrogen can appear in human milk. Proteins triggered by T3 remain in the body and have their own life cycle beyond T3s clearance. Patients should not use Thyrogen with radioiodine if they have a contraindication to the use of radioiodine. restlessness. The above mentioned symptoms improved as I brought the dose and levels down (which made the tsh levels higher). Abrupt discontinuation of SSRIs that have shorter half-lives, such as paroxetine, may induce withdrawal symptoms, some of which may mimic a recurrence of a depressive episode (eg, tiredness, irritability, severe somatic symptoms). Thyroid Hormone Withdrawal (THW) may result in . It can be taken by mouth or by injection into a vein.. Side effects may occur from excessive doses. The Pharmacodynamic Equivalence of Levothyroxine and Liothyronine. But you have to ask yourself a very important question: Are their experiences, medical conditions, circumstances, etc. If you suddenly stop taking that medication your body will not be able to produce its own thyroid hormone (usually for days to weeks) and during this time period, you will most likely feel terrible. If the patient has no symptoms before treatment (just a low temperature). Withdrawal symptoms of suddenly stopping certain antidepressants include anxiety, chills, difficulty sleeping, dizziness, headaches, increased depression symptoms, irritability, muscle aches, nausea, sensations of electric shock, sleepiness, and vivid dreams. It is created by eHealthMe based on reports of 6,191 people who have side effects when taking Cytomel from the FDA, and is updated regularly. Follow me on Facebook, TikTok, and Instagram for up-to-date thyroid tips, tricks, videos, and more. 1984. And when I say important, thats really an understatement. It often results in the construction of new proteins. Cytomel T3,cytomel dosage -cytomel reviews - how to take cytome l Ive done research and came to find out that bodybuilders c Low intracellular T3 secondary to hypothyroidism is the basic underlying pathology in myxedema crisis which leads to hypothermia and suppression of cardiac activity. Mol Imaging Radionucl Ther. A half life can be misleading when the clearance rate is skewed, as it is in LT3 dosing. In case you arent already aware, another very important factor that is within your control is the food that you put into your body and how much you exercise. This can definitely but difficult, but Ive put together some resources to help. In most cases, you will find the answer to that question is no. The peak clears from blood within a few hours, followed by a very long tail. Myxedema Coma: A New Look into an Old Crisis. Journal of Thyroid Research 2011. https://doi.org/10.4061/2011/493462. 1 white pill Synthroid - 50 mcg T4. Thats also a very severe level of hypothyroidism. As with any opiod drugs, it's best to avoid buying Cytomel T3 . Lum et al 1984 (over)dosed euthyroid people on LT3 for 4 weeks to compare their clearance with hypothyroid people. Clearly, we do not all metabolize or clear T3 at the same rate. If possible, offer to help with these tasks so your loved one can focus on healing. You will be required to stop taking it for about 2 weeks before receiving RAI to make sure your TSH level is high enough for the . How long does Cytomel stay in your system? - Drugs.com The chances of this happening are slim, but the chances of stopping thyroid medication and feeling better are also slim. Thyroid hormone receptors may become more sensitive to T3, since the opposite is true (temporary receptor insensitivity) in persons with higher T3 levels. abdominal cramps. Fatigue or muscle weakness. Like all bodybuilding steroids, Anavar suppresses natural testosterone. Obtain ethical informed consent from the patient first, and offer alternatives. So, your 5 mcg of Cytomel is equivalent to 20 mcg of Levoxyl. Individuals vary slightly in their rate of absorption and clearance, as shown in the TT3 graph. Increased weight gain. Withdrawal symptoms of cytomel - Thyroid Disorders - MedHelp severe headache. Cytomel. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. I went out of the country with out my prescription for cytomel. muscle aches, weakness, or cramps. So, if you decide to stop taking your medication your body can only produce the amount that it is capable of producing. A Randomized, Double Blind, Cross-over Study in Thyroidectomized Patients. Clinical Endocrinology 72 (5): 70915. Side effects of discontinuing levoxyl - Dr. Farwa Tauseef Different symptoms and health impacts appear at different points on the way to thyroid hormone depletion. Levothyroxine is used to treat low thyroid hormone levels in your body, called hypothyroidism 2. cytomel withdrawal symptoms - Fashionexclusiveuae.com I love to write and share what I've learned over the years. You can use the study as a second opinion to make health care decisions. It does sound like the hormones left in your system are still pretty high. This may be an option for some people, but again, it should not be done without physician supervision. The answer is that it depends. Recovery of pituitary thyrotropic function after withdrawal of prolonged thyroid-suppression therapy. 1980. (It seems quite ridiculous to give people large single doses of thyroid hormone when they dont need it. Use in pregnancy and breastfeeding is . https://doi.org/10.1089/thy.2019.0101. The Interaction Between Thyroid and Kidney Disease: An Overview of the Evidence. Current Opinion in Endocrinology, Diabetes, and Obesity 23 (5): 40715. Remember, we said that thyroid hormone is required for you to function and for you to live. The week before I was on nothing, prior to that, thyroxine. When you use supplements make sure that you find very high-quality supplements, and make sure that you are using it for your desired outcome. Thyrogen is also used to help patients prepare for treatment with a form of iodine, called radioiodine, to remove leftover thyroid tissue in patients who have had surgery to take out the entire thyroid gland for patients with well differentiated thyroid cancer who do not have signs of thyroid cancer which has spread to other parts of the body. In most cases, if you stop taking your medication cold turkey, you will experience many negative side effects. Therefore, signalling effects linger on even after the T3 is no longer bound to the receptor and is depleted from blood. The main difference between the heart and other tissues when it comes to thyroid hormone is the effects at the cellular level: In addition, Cytomel often needs to be taken multiple times a day since it has a short half-life, resulting in fluctuating levels in the body. at home. Experts calculate this period using the half-life of a drug. nausea and vomiting. * Approximation only. The half-life of the T3 preparation was calculated as 22 hours when the decline in T3 concentration between 2.5 and 94 hours was employed.. The quantitative results were as follows: The Quality of Life scores were equally poor for LT4 and LT3 withdrawal, the maximum score for the poorest quality of life being 31. The lines for serum are almost straight. Nervousness, anxiety, panic attacks. They want to know what would happen if they unexpectedly ran out of supply due to a pharmaceutical shortage, a health care system breakdown, or if they were unable to access their medicine cabinet for a few weeks. #1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1980928/, #2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585732/, #3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737508/, #4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784889/, #5. https://www.ncbi.nlm.nih.gov/books/NBK278958/, #6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682381/. Hashimoto's thyroiditis. Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance) is found to be associated with 1,809 drugs and 1,379 conditions by eHealthMe. That means you will NEED to take thyroid medication for the rest of your life. Patients over 65 years old with large amounts of leftover thyroid tissue after surgery, or with a history of heart disease, should discuss with their physicians the risks and benefits of Thyrogen. Lastly, and perhaps the most important thing you can do is to try and find a physician or Doctor who is willing and able to help you with your condition. COMMON side effects If experienced, these tend to have a Severe expression i . N . In people with healthy thyroid glands, the rise and fall in Free T3 and Total T3 is parallel over time. Meth Withdrawal Symptoms, Timeline & Detox Treatment cytomel withdrawal symptoms - Manoharinternational.com pain or discomfort in the arms, jaw, back, or neck. Genital symptoms (0-3) were also overemphasized compared to fatigue. Perhaps men designed this survey? severe headaches, ringing in your ears, dizziness, vision problems, pain behind your eyes; a seizure; or. Are you struggling with getting proper thyroid care? Other symptoms may include delayed reflexes (such as the knee jerk when the knee is hit with a reflex hammer), brittle nails, increased blood pressure, and a slow heart rate. It was a modified version of the self-rating Kellner symptoms questionnaire, the Hamilton depression scale, and Lusters 13-item scale for measurement of hypothyroidism. They cherry-picked from these 3 sources, and then they did not adapt it to the situation very well at all. cytomel withdrawal symptoms - Epcorcentre.org Sign up to receive 20% off your first order. Patients experience significantly less depression, anxiety and psychomotor retardation while on their thyroid hormone medication. If you know that you have low T3 or have a problem converting thyroid hormone, then taking a supplement designed for improving T3 conversion is probably ideal. eHealthMe is studying from 6,950 Cytomel users for its effectiveness, alternative drugs and more. After withdrawal, some symptoms do not appear until after the medication has disappeared from circulation, due to the long-term and cumulative nature of thyroid hormone signalling. . We are not responsible for the content or availability of linked sites. Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance) is found to be associated with 1,764 drugs and 1,361 conditions by eHealthMe. T3 and T4 will require a physicians supervision. Weigh pro's and con's of treatment (see Q2). June 5. cytomel withdrawal symptoms . See what others have said about Cytomel (Liothyronine), including the effectiveness, ease of use and side effects. Triiodothyronine (Cytomel) plus any antidepressant. Alpha Lipoic Acid (ALA) and Thyroid Health: Is it Safe to Use? Dutta, Pinaki, Anil Bhansali, Shriq Rashid Masoodi, Sanjay Bhadada, Navneet Sharma, and Rajesh Rajput. There's a Nationwide Shortage of Levothyroxine. This is Why Post-acute and protracted withdrawal symptoms from meth can include: 3. Withdrawal symptoms of cytomel. In thyroid therapy, one must ask, half life in what kind of patient?. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider.
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Jeff Francoeur Salary, Articles C